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The IL-33/ST2 pathway — A new therapeutic target in cardiovascular disease

✍ Scribed by Ashley M. Miller; Foo Y. Liew

Book ID: 113846104
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 554 KB
Volume: 131
Category: Article
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2011.02.005

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## Background: St2 has been proposed to be a regulator of inflammation and th1/th2 balance. st2l is the il-33 membrane receptor and belongs to the il-1r family. the soluble variant, st2s, is identical to the extracellular region of st2l and competes for il-33 binding, inhibiting receptor signaling.