The Identity of the Cells that Positively Select Thymocytes
โ Scribed by J. I. Elliott
- Book ID
- 111247690
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 535 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0105-2896
No coin nor oath required. For personal study only.
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## Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion* We set out to determine whether thymocytes from Tcell receptor (TCR) transgenic animals specific for a class I-restricted determinant from ovalbumin (OVA) showed the same fine specif
The past year has been marked by the application of new technologies to study thymocyte development. These studies have shown that positive selection affects a surprisingly large proportion of thymocytes, and now are beginning to investigate the affinities/avidities of the reactions involved. The le
cells bearing the โฃโค T-cell receptor (TCR) complex recognize antigen in the form of peptide fragments bound to proteins encoded by the host major histocompatibility complex (MHC). Because of the random recombination events regulating generation of the specificity of TCRโฃ and TCRโค proteins, T cells a