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Positive selection of thymocytes bearing αβ T cell receptors

✍ Scribed by Philippa Marrack; John Kappler

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
555 KB
Volume
9
Category
Article
ISSN
0952-7915

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✦ Synopsis

The past year has been marked by the application of new technologies to study thymocyte development. These studies have shown that positive selection affects a surprisingly large proportion of thymocytes, and now are beginning to investigate the affinities/avidities of the reactions involved. The lengthy controversy over how thymocytes decide whether to express CD4 or CD8 has taken a new turn with the discovery that levels of expression of the fate-determining protein Notch may affect the decision.

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