The Ideal Thrombolytic Agent: GISSI-2 and ISIS-3
β Scribed by ALDO PIETRO. MAGGIONI; CLAUDIO. FRESCO; MARIA GRAZIA. FRANZOSI; GIANNI. TOGNONI; GISSI-2 INVESTIGATORS
- Book ID
- 109214722
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 880 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0896-4327
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Conformationally restricted analogues of the antibacterial agent trimethoprim (TMP) were designed to mimic the conformation of drug observed in its complex with bacterial dihydrofolate reductase (DHFR). This conformation of TMP was achieved by linking the 4-amino function to the methylene group by o