Synthesis of the hypotensive agent 8-amino-7-[2-hydroxy-3-morpholinopropyl]theophylline (P23) and analogs
β Scribed by Marek T. Cegla; Joanna Potaczek; Marek Zylewski; Lucjan Strekowski
- Book ID
- 102344991
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2009
- Tongue
- English
- Weight
- 167 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.51
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β¦ Synopsis
Abstract
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Synthesis of a number of 7,8βdisubstituted theophyllines including enantiomers of the hypotensive agent P23 is described. J. Heterocyclic Chem., (2009)
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Use of an Iodonium Ylide in the Synthesis of p-Nitrobenzyl (6R,7S) 3-Hydroxy-8-oxo-7-phenoxyacetamido-1-azabicyclo [4.2.0]octa-2-ene-2-carboxylate. -The title compound (IV), a key intermediate in the synthesis of carbacephalosporins, is prepared by Rh(II)-catalyzed cyclization of the iodonium ylide