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The hydration of sterically hindered epoxides by epoxide hydrolase of the rat and rabbit

✍ Scribed by C.H. Walker; C.W. Timms; C.R. Wolf; F. Oesch

Book ID
115778882
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
553 KB
Volume
35
Category
Article
ISSN
0006-2952

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✍ R. Sellman; M. G. Parkki πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 405 KB πŸ‘ 1 views

The effects of tienilic acid [ 2,3-dichloro-4-(2-thienylcarbonyl)phenoxy acetic acid] on drug-metabolizing enzymes in the rat liver and kidneys were studied. Short-term treatment for 2 weeks (450 mg per kg per day) increased the activity of microsomal epoxide hydrolase at least two-fold in both rat