𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The Humanities in Canadaby Watson Kirkconnell; A. S. P. Woodhouse

✍ Scribed by Review by: E. K. Brown

Book ID
125015330
Publisher
Blackwell Publishing
Year
1948
Weight
444 KB
Volume
14
Category
Article
ISSN
0315-4890

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Stereoselectivity in the oxidation of bu
Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s
✍ Shizuo Narimatsu; Chie Takemi; Shino Kuramoto; Daisuke Tsuzuki; Hiroyuki Hichiya πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 151 KB

## Abstract Bufuralol (BF), a nonselective β‐adrenoceptor blocking agent, has a chiral center in its molecule, yielding the enantiomers 1β€²__R__‐BF and 1β€²__S__‐BF. β‐Adrenoceptor blocking potency is much higher in 1β€²__S__‐BF than in 1β€²__R__‐BF. One of the metabolic pathways of BF is 1″‐hydroxylation