Antitumor activity of vinzolidine in the
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Bonnie J. Takasugi; Sydney E. Salmon; Robert L. Nelson; Laurie Young; Rosa M. Li
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Article
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1984
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Springer US
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English
β 390 KB
Vinzolidine (VZL), a semisynthetic vinblastine (VLB) derivative, was tested against a variety of solid tumors in the human tumor clonogenic assay (HTCA). The emphasis was on continuous drug exposure because of the schedule-dependency of the vincas and long half-life of VZL. Of tumor types with more