The human T cell antigen Leu-2 (T8) is encoded on chromosome 2

✍ Scribed by G. Bruns; P. Kavathas; Y. Shiloh; K. Sakai; J. Schwaber; S. A. Latt; L. A. Herzenberg

• Book ID: 104709558
• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 415 KB
• Volume: 70
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00295366

✦ Synopsis

The locus encoding the human T lymphocyte cell surface antigen Leu-2 has been assigned to chromosome 2 with a DNA mapping panel derived from somatic cell hybrids. The two genomic components identified by a cDNA clone for Leu-2 segregated with human chromosome 2 in all 24 independent hybrid clones examined. The cosegregation of the Leu-2 and immunoglobulin kappa (IgK) loci in hybrids with spontaneous rearrangements of chromosome 2 is consistent with the possibility that the Leu-2 locus is on proximal human 2p near IgK. In the mouse, a locus for a T lymphocyte cell surface antigen with properties similar to Leu-2 is closely linked to the IgK locus on mouse chromosome 6. Hence the syntenic relationship of a gene implicated in T cell killing with the immunoglobulin kappa locus would then be conserved in the mouse and human genomes.