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The gene coding for the human T-lymphocyte CD2 antigen is located on chromosome 1p

✍ Scribed by Marion H. Brown; Patricia A. Gorman; William A. Sewell; Nigel K. Spurr; Denise Sheer; Michael J. Crumpton

Publisher
Springer
Year
1987
Tongue
English
Weight
486 KB
Volume
76
Category
Article
ISSN
0340-6717

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✦ Synopsis

A cDNA clone encoding the human T lymphocyte sheep erythrocyte receptor [the CD2 (T11) antigen] was used as a probe to define the chromosomal location of the gene. The signal, revealed by hybridisation to Southern blots of genomic DNA from somatic cell hybrids, showed a high degree of concordance for human chromosome 1. In particular, the hybrid F4Sc13C19 which contained the short arm only of human chromosome 1 was positive. The location of the CD2 gene to 1p13 was confirmed by in situ hybridisation.

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