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The Human ROX Gene: Genomic Structure and Mutation Analysis in Human Breast Tumors

โœ Scribed by Cristiana Lo Nigro; Tiziana Venesio; Alexandre Reymond; Germana Meroni; Paola Alberici; Silvia Cainarca; Fiorenza Enrico; Maria Stack; David H. Ledbetter; Daniel S. Liscia; Andrea Ballabio; Romeo Carrozzo


Book ID
115614273
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
194 KB
Volume
49
Category
Article
ISSN
0888-7543

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Genomic structure and mutation screening
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E2F4, a member of the E2F family of transcription factors, is abundant in non-proliferating and differentiated cells where it plays an important role in the suppression of proliferation-associated genes. The E2F4 gene spans 6 kb and has 10 exons. It contains a serine (CAG) repeat tract in exon 7, wh