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The Human Mammary-Derived Growth Inhibitor (MDGI) Gene: Genomic Structure and Mutation Analysis in Human Breast Tumors

โœ Scribed by Catherine M. Phelan; Catharina Larsson; Stephen Baird; P.Andrew Futreal; M.H. Ruttledge; Kenneth Morgan; Patricia Tonin; Huynh Hung; Robert G. Korneluk; Michael N. Pollak; Steven A. Narod


Book ID
115613197
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
142 KB
Volume
34
Category
Article
ISSN
0888-7543

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Genomic structure and mutation screening
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E2F4, a member of the E2F family of transcription factors, is abundant in non-proliferating and differentiated cells where it plays an important role in the suppression of proliferation-associated genes. The E2F4 gene spans 6 kb and has 10 exons. It contains a serine (CAG) repeat tract in exon 7, wh