✦ LIBER ✦

The human NME2 gene lies within 18kb of NME1 in chromosome 17

✍ Scribed by Settara C. Chandrasekharappa; Laura A. Gross; Stephanie E. King; Francis S. Collins

Book ID: 102221196
Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 360 KB
Volume: 6
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870060411

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✦ Synopsis

The NMEl gene, localized to human chromosome I 7 at q22, shows reduced expression in tumors of high metastatic potential. A homologous gene, N M U , with similar reduced expression in breast carcinoma, has recently been reported. W e have isolated and characterized five yeast artificial chromosome (YAC) clones and three cosmid clones that contain both genes, demonstrating that the NMEZ gene is also located on chromosome I 7 and is separated by not more than I8 kb from the NME / gene. The two putative tumor suppressor genes, encoding the two polypeptide chains of nucleoside diphosphate (NDP) kinase, are thus quite close to each other on chromosome 17, indicating that they may well have arisen by a tandem duplication. Both genes now appear to be excluded as candidates for the early-onset breast cancer (BRCAI) locus. Genes Chrom Cancer 6245-248

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