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The human KB multidrug-resistant cell line KB-C1 is hypersensitive to inhibitors of glycosylation

โœ Scribed by J. Bentley; D.M. Quinn; R.S. Pitman; J.R. Warr; G.L. Kellett

Book ID
117468943
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
798 KB
Volume
115
Category
Article
ISSN
0304-3835

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In this study we show that multidrug-resistant (MDR) human KB-VI cells are highly resistant to the cytotoxicity of okadaic acid and calyculin A, 2 toxins from marine sponges that are potent inhibitors of type-I and type-2A protein phosphatases (PPl and PP2A). Cytotoxicity and colony-forming assays i