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The Human Insulin Receptor Substrate-1 Gene (IRS1) Is Localized on 2q36

✍ Scribed by Masaki Nishiyama; Johji Inazawa; Takeshi Ariyama; Yusuke Nakamura; Senya Matsufuji; Akihiro Furusaka; Teruji Tanaka; Shin-ichi Hayashi; Jack R. Wands


Book ID
115612008
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
203 KB
Volume
20
Category
Article
ISSN
0888-7543

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Human insulin receptor substrate-1 gene
✍ M. Stoffel; R. Espinosa; S. R. Keller; G. E. Lienhard; M. M. Le Beau; G. I. Bell πŸ“‚ Article πŸ“… 1993 πŸ› Springer 🌐 English βš– 488 KB

The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (noninsulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in