Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism
✍ Scribed by M. Stoffel; R. Espinosa; S. R. Keller; G. E. Lienhard; M. M. Le Beau; G. I. Bell
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 488 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0012-186X
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✦ Synopsis
The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (noninsulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in order to study the role of genetic variation in this gene in the pathogenesis of diabetes mellitus. As a first step in these studies, we have mapped the IRS-1 gene to chromosome 2, bands q35-q36.1 and identified a simple tandem repeat DNA polymorphism in this gene that will be useful for genetic studies.