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The human drug metabolizing cytochromes P450

✍ Scribed by Steven A. Wrighton; Mark VandenBranden; Barbara J. Ring


Book ID
112736782
Publisher
Springer
Year
1996
Tongue
English
Weight
682 KB
Volume
24
Category
Article
ISSN
1573-8744

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Hydroxylation of diclofenac: an illustra
✍ Samya Othman; Virginie Mansuy-Mouries; Claude Bensoussan; Pierrette Battioni; Da πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 200 KB

Preparative hydroxylation of aromatic compounds such as drugs remain a difficult challenge. Here we show that the two main human metabolites of the anti-inflammatory drug diclofenac, 5-hydroxy-and 4%-hydroxy-diclofenac, can be prepared from diclofenac in high yields by using two complementary model