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The human corticosteroid binding globulin gene is located on chromosome 14q31–q32.1 near two other serine protease inhibitor genes

✍ Scribed by Gilles-Eric Seralini; Dominique Bérubé; Richard Gagné; Geoffrey L. Hammond

Book ID
104663292
Publisher
Springer
Year
1990
Tongue
English
Weight
492 KB
Volume
86
Category
Article
ISSN
0340-6717

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✦ Synopsis

Human corticosteroid binding globulin (CBG) cDNA fragments were radiolabeled and hybridized in situ to metaphase chromosome preparations. The results localized the CBG gene to the q31-q32.1 region of human chromosome 14. This location also contains the genes for two closely related serine protease inhibitors: alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin. It is therefore likely that these genes evolved by duplication events, and it would appear that this region contains a series of functionally related genes.

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