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The human cardiac troponin I locus: assignment to chromosome 19p13.2–19q13.2

✍ Scribed by Catriona MacGeoch; Paul J. R. Barton; William J. Vallins; Pankaj Bhavsar; Nigel K. Spurr

Publisher
Springer
Year
1991
Tongue
English
Weight
557 KB
Volume
88
Category
Article
ISSN
0340-6717

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✦ Synopsis

The three major troponin I isoforms are encoded by separate genes and are expressed in a muscle-type-specific manner. A human cardiac troponin I cDNA has recently been isolated and used to establish the genomic location of the cardiac troponin I gene locus (designated TNNC1). By somatic cell hybrid analysis, the locus for TNNC1 maps to human chromosome 19 and can be localised to the region p13.2-q13.2.

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