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Assignment of the gene coding for human cytochromecoxidase subunit VIb to chromosome 19, band q13.1, by fluorescence in situ hybridisation

โœ Scribed by Jan-Willem Taanman; Anneke Y. Veen; Cobi Schrage; Hans Vries; Charles H. C. M. Buys


Publisher
Springer
Year
1991
Tongue
English
Weight
762 KB
Volume
87
Category
Article
ISSN
0340-6717

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โœฆ Synopsis


A cloned, 40 kb, genomic DNA fragment, containing the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking sequences, was used as a probe to localize the subunit VIb gene on human metaphase chromosomes. The probe was labelled with Bio-11-dUTP and detected by fluorescence. Subsequent R-banding indicated that the cytochrome c oxidase subunit VIb gene is localized in band 19q13.1, extending the evidence that the human nuclear genes of cytochrome c oxidase are not clustered.


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