The human biliary epithelial cell plasma membrane antigen in primary biliary cirrhosis: Pyruvate dehydrogenase X?
β Scribed by RE Joplin; LL Wallace; JG Lindsay; JM Palmer; SJ Yeaman; JM Neuberger
- Book ID
- 119755841
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 319 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC). The portal tract T-cell infiltrate and up-regulation of HLA class I, HLA class 11, and c
Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the serum of more than 95% of patients with primary biliary cirrhosis (PBC), the major epitope being the inner lipoyl domain of the E2 component. Immunoblotting suggests a similar prevalence of antibodies to a tightly associat