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The Human and Mouse Complement of SH2 Domain Proteins—Establishing the Boundaries of Phosphotyrosine Signaling

✍ Scribed by Bernard A. Liu; Karl Jablonowski; Monica Raina; Michael Arcé; Tony Pawson; Piers D. Nash


Book ID
116754254
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
862 KB
Volume
22
Category
Article
ISSN
1097-2765

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Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. Here we report on the structural dynamic effects upon interaction of a phosphopeptide liga