Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains
β Scribed by Robert B. Russell; Jason Breed; Geoffrey J. Barton
- Book ID
- 115926265
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 734 KB
- Volume
- 304
- Category
- Article
- ISSN
- 0014-5793
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Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. Here we report on the structural dynamic effects upon interaction of a phosphopeptide liga
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