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The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells

✍ Scribed by Trus, M R; Yang, L; Suarez Saiz, F; Bordeleau, L; Jurisica, I; Minden, M D


Book ID
110056295
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
372 KB
Volume
19
Category
Article
ISSN
0887-6924

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## Abstract ## BACKGROUND Valproic acid (VPA) inhibits histone deacetylase activity and, synergizing with all‐trans retinoic acid (ATRA), achieves differentiation induction of myeloid blast cells in vitro. ## METHODS We used VPA in 58 patients with acute myeloid leukemia (AML) who were too old a