The histone deacetylase (HDAC) inhibitor
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Andrea Kuendgen; Mathias Schmid; Richard Schlenk; Sabine Knipp; Barbara Hildebra
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Article
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2006
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John Wiley and Sons
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English
β 116 KB
π 2 views
## Abstract ## BACKGROUND Valproic acid (VPA) inhibits histone deacetylase activity and, synergizing with allβtrans retinoic acid (ATRA), achieves differentiation induction of myeloid blast cells in vitro. ## METHODS We used VPA in 58 patients with acute myeloid leukemia (AML) who were too old a