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The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances taxol-induced cell death in breast cancer

✍ Scribed by Yi-kang Shi; Zhong-hua Li; Xi-qian Han; Ji-hu Yi; Zhen-hua Wang; Jing-li Hou; Cong-ran Feng; Qing-hong Fang; Hui-hui Wang; Peng-fei Zhang; Feng-shan Wang; Jie Shen; Peng Wang


Publisher
Springer
Year
2010
Tongue
English
Weight
622 KB
Volume
66
Category
Article
ISSN
0344-5704

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Histone deacetylase inhibitor, suberoyla
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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th