Histone deacetylase inhibitor, suberoyla
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Takashi Kumagai; Naoki Wakimoto; Dong Yin; Sigal Gery; Norihiko Kawamata; Noriyu
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Article
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2007
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John Wiley and Sons
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French
β 461 KB
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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th