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Inhibition of histone deacetylase enhances the anti-proliferative action of antiestrogens on breast cancer cells and blocks tamoxifen-induced proliferation of uterine cells

✍ Scribed by Leslie Hodges-Gallagher; Cathleen D. Valentine; Suzy El Bader; Peter J. Kushner


Publisher
Springer US
Year
2006
Tongue
English
Weight
568 KB
Volume
105
Category
Article
ISSN
0167-6806

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Since estrogens play a predominant role in the development and growth of human breast cancer, antiestrogens represent a logical approach to the treatment of this disease. The present study compares the effects of the novel nonsteroidal anti-estrogen EM-800 and related compounds with those of a serie