## Abstract Arsenic trioxide (As~2~O~3~) is one of the arsenic compounds found in nature. As~2~O~3~ has recently been used to treat patients suffering from retinoic acid receptor (AML). It is of clinical interest to investigate whether As~2~O~3~ is also effective in treating solid tumors. Here, we
β¦ LIBER β¦
Inhibition of histone deacetylase enhances the anti-proliferative action of antiestrogens on breast cancer cells and blocks tamoxifen-induced proliferation of uterine cells
β Scribed by Leslie Hodges-Gallagher; Cathleen D. Valentine; Suzy El Bader; Peter J. Kushner
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 568 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0167-6806
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Since estrogens play a predominant role in the development and growth of human breast cancer, antiestrogens represent a logical approach to the treatment of this disease. The present study compares the effects of the novel nonsteroidal anti-estrogen EM-800 and related compounds with those of a serie