The Hippo Signaling Pathway and Cancer

✍ Scribed by Moshe Oren, Yael Aylon (auth.), Moshe Oren, Yael Aylon (eds.)

Publisher: Springer-Verlag New York
Year: 2013
Tongue: English
Leaves: 344
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer. The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience are researchers interested in basic science in the areas of tumor suppression, cell cycle and size regulation, development and differentiation.

✦ Table of Contents

Front Matter....Pages i-vi
Introduction....Pages 1-8
Front Matter....Pages 9-9
Merlin and Angiomotin in Hippo-Yap Signaling....Pages 11-25
MST1/2 and Other Upstream Signaling that Affect Hippo Pathway Function....Pages 27-49
Front Matter....Pages 51-51
YAP1 Uses Its Modular Protein Domains and Conserved Sequence Motifs to Orchestrate Diverse Repertoires of Signaling....Pages 53-70
Regulation of YAP and TAZ Transcription Co-activators....Pages 71-87
Regulation of YAP and TAZ by Epithelial Plasticity....Pages 89-113
Front Matter....Pages 115-115
Hippo Pathway and Apoptosis....Pages 117-145
YAP and p73: A Matter of Mutual Specificity in Tumor Suppression....Pages 147-172
The c-Abl/YAP/p73 Apoptotic Module and the HIPPO Pathway....Pages 173-195
Front Matter....Pages 197-197
Hippo in Cell Cycle and Mitosis....Pages 199-221
Front Matter....Pages 223-223
Hippo and Mouse Models for Cancer....Pages 225-247
Roles of Hippo Signaling During Mouse Embryogenesis....Pages 249-264
Hippo Signaling and Stem Cells....Pages 265-279
Hippo Signaling and Organ Size Control....Pages 281-291
Hippo Signaling in Heart Development....Pages 293-304
Front Matter....Pages 305-305
Cell Competition and the Hippo Pathway....Pages 307-325
Non-canonical Roles for the Hippo Pathway....Pages 327-346
Back Matter....Pages 347-354

✦ Subjects

Cancer Research; Cell Biology; Medical Microbiology; Biomedicine general

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