Signaling Pathways in Cancer Pathogenesis and Therapy

✍ Scribed by David A. Frank (auth.), David A. Frank (eds.)

• Publisher: Springer-Verlag New York
• Year: 2012
• Tongue: English
• Leaves: 157
• Edition: 1
• Category: Library

✦ Synopsis

In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.

✦ Table of Contents

Front Matter....Pages i-viii
Signaling Pathways in Cancer: Twenty-First Century Approaches to Cancer Therapy....Pages 1-3
Current and Next Generation Antimitotic Therapies in Cancer....Pages 5-21
DNA Damage Checkpoint Signaling Pathways in Human Cancer....Pages 23-37
Nonreceptor Tyrosine Kinases and Their Roles in Cancer....Pages 39-53
The Hedgehog Signaling Pathway in Cancer Pathogenesis and Therapy....Pages 55-79
Wnt Signaling in Cancer Pathogenesis and Therapeutics....Pages 81-94
STAT Signaling in the Pathogenesis and Treatment of Cancer....Pages 95-108
Protein Therapeutics in Oncology....Pages 109-144
Back Matter....Pages 145-148

✦ Subjects

Cancer Research; Pharmacology/Toxicology