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The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter

✍ Scribed by Subhodeep Sarker; René Weissensteiner; Ilka Steiner; Harald H Sitte; Gerhard F Ecker; Michael Freissmuth; Sonja Sucic


Publisher
BioMed Central
Year
2010
Tongue
English
Weight
94 KB
Volume
10
Category
Article
ISSN
1471-2210

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✦ Synopsis


Sarker et al.: The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. BMC Pharmacology 2010 10(Suppl 1):A21.


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✍ David Moscatelli 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 834 KB

Scatchard analysis of binding of 125I-basic fibroblast growth factor (FGF) to baby hamster kidney (BHK) cells revealed the presence of two binding sites: a high affinity site with KD of 20 pM and 80,000 sites per cell and a low affinity site with KD of about 2 nM and 600,000 sites per cell. The bind