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The Heme and Sickle Cell Hemoglobin Polymerization

✍ Scribed by Vekilov, Peter G.; Uzunova, Veseilina; Pan, Weichun

Book ID
119206178
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
32 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract We probe the role of free heme in the interactions between sickle cell hemoglobin (HbS) molecules in simulated physiological solutions: polymerization of deoxy‐HbS is the primary pathogenic event of sickle cell anemia, and HbS releases heme after autoxidation more readily than normal ad