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Free Heme and the Polymerization of Sickle Cell Hemoglobin

✍ Scribed by Uzunova, Veselina V.; Pan, Weichun; Galkin, Oleg; Vekilov, Peter G.

Book ID
119207455
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
494 KB
Volume
99
Category
Article
ISSN
0006-3495

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πŸ“œ SIMILAR VOLUMES

Free heme in micromolar amounts enhances
Free heme in micromolar amounts enhances the attraction between sickle cell hemoglobin molecules
✍ Weichun Pan; Veselina V. Uzunova; Peter G. Vekilov πŸ“‚ Article πŸ“… 2009 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 282 KB

## Abstract We probe the role of free heme in the interactions between sickle cell hemoglobin (HbS) molecules in simulated physiological solutions: polymerization of deoxy‐HbS is the primary pathogenic event of sickle cell anemia, and HbS releases heme after autoxidation more readily than normal ad

Crowding and the polymerization of sickl
Crowding and the polymerization of sickle hemoglobin
✍ Frank A. Ferrone; Maria A. Rotter πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 135 KB

## Abstract Under physiological conditions, sickle hemoglobin, a natural mutant of human hemoglobin A with a surface hydrophobic valine in place of a negatively charged glutamic acid, polymerizes at high volume occupancy. Equilibrium solubility of sickle hemoglobin entails activity coefficients tha