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The H-phosphonate approach to oligonucleotide synthesis. An investigation on the mechanism of the coupling step

โœ Scribed by Sigurdsson, Susannah; Str??mberg, Roger


Book ID
111649892
Publisher
Royal Society of Chemistry
Year
2002
Tongue
English
Weight
173 KB
Volume
10
Category
Article
ISSN
1472-779X

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Tris(l,l,l, 3, 3, ) phosphite was used as a phosphonylatin E reaEent for the preparation of nucleoside 3'-H-phosphonate units. The use of a new couplin E reaEent, 1,3-dimethyl-2-chloro-imidazolinium chloride (DMCI) for the internucleotidic H-phosphonate bond formation via the H-phosphonate approa