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The gould-jacob type of reaction for the synthesis of novel pyrimidopyrrolopyrimidines: A comparison of classical heating vs solvent free microwave irradiation

โœ Scribed by Nirmal D. Desai

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
295 KB
Volume
43
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

The Gould-Jacob type of reaction for the synthesis of ethyl 4-oxo-8,10-substituted-4,8-dihydropyrimido[1,2c]pyrrolo [3,2-e]pyrimidine-3-carboxylates 5 has been carried out conventionally by the condensation between 4aminopyrrolo[2,3-d]pyrimidines 2 and diethyl ethoxymethylenemalonate 3 via acyclic intermediates diethyl N- [5,7-substituted-7H-pyrrolo[2,3-d]pyrimidin-4-yl]aminomethylenemalonates 4 and the results obtained were compared with single step microwave irradiation under solvent free conditions for the synthesis of 5.

๐Ÿ“œ SIMILAR VOLUMES

The Gouldโ€”Jacob Type of Reaction for the
The Gouldโ€”Jacob Type of Reaction for the Synthesis of Novel Pyrimidopyrrolopyrimidines: A Comparison of Classical Heating vs. Solvent-Free Microwave Irradiation.
โœ Nirmal D. Desai ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons โš– 24 KB

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