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The Glucuronidation of Exogenous and Endogenous Compounds by Stably Expressed Rat and Human UDP-Glucuronosyltransferase 1.1

โœ Scribed by Christopher D. King; Mitchell D. Green; Gladys R. Rios; Birgit L. Coffman; Ida S. Owens; Warren P. Bishop; Thomas R. Tephly


Book ID
115566151
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
134 KB
Volume
332
Category
Article
ISSN
0003-9861

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The effect of valproic acid on drug and
โœ Brian T Ethell; Gail D Anderson; Brian Burchell ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 187 KB

Valproic acid glucuronidation kinetics were carried our with three human UGT isoforms: UGT1A6, UGT1A9, and UGT2B7 as well as human liver and kidney microsomes. The glucuronidation of valproic acid was typified by high K(m) values with microsomes and expressed UGTs (2.3-5.2mM). The ability of valproi