Glucuronidation of Catechol Estrogens by Expressed Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7
β Scribed by Ziqiang Cheng; Gladys R. Rios; Christopher D. King; Birgit L. Coffman; Mitchell D. Green; Behnaz Mojarrabi; Peter I. Mackenzie; Thomas R. Tephly
- Book ID
- 112268793
- Publisher
- Oxford University Press
- Year
- 1998
- Tongue
- English
- Weight
- 73 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1096-6080
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π SIMILAR VOLUMES
Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) enzymes is an important pathway in the metabolism of drugs as well as environmental chemicals. In this study, protein-protein interactions between human UGT2B7 and UGT1As and their effects on the enzymatic activities were investigated us
## Abstract Stereoselective metabolism of propranolol sideβchain glucuronidation was studied for two recombinant human uridine diphosphate glucuronosyltransferases (UGTs), UGT1A9 and UGT2B7. The __S__β and __R__βpropranolol sideβchain glucuronides produced in the incubation mixtures were assayed si