Substrate-Dependent Modulation of UDP-Glucuronosyltransferase 1A1 (UGT1A1) by Propofol in Recombinant Human UGT1A1 and Human Liver Microsomes
β Scribed by Yuji Mano; Takashi Usui; Hidetaka Kamimura
- Book ID
- 111316366
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 137 KB
- Volume
- 101
- Category
- Article
- ISSN
- 1742-7835
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π SIMILAR VOLUMES
Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) enzymes is an important pathway in the metabolism of drugs as well as environmental chemicals. In this study, protein-protein interactions between human UGT2B7 and UGT1As and their effects on the enzymatic activities were investigated us
Chenodeoxycholic acid (CDCA) is a liver-formed detergent and plays an important role in the control of cholesterol homeostasis. During cholestasis, toxic bile acids (BA) accumulate in hepatocytes causing damage and consequent impairment of their function. Glucuronidation, a conjugation reaction cata