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The GGN and CAG repeat polymorphisms in the exon-1 of the androgen receptor gene are, respectively, associated with insulin resistance in men and with dyslipidemia in women

✍ Scribed by Germán Rodríguez-González; Raquel Ramírez-Moreno; Patricia Pérez; Cristina Bilbao; Laura López-Ríos; Juan C. Díaz-Chico; Pedro C. Lara; Lluis Serra-Majem; Ricardo Chirino; B. Nicolás Díaz-Chico


Book ID
116698279
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
365 KB
Volume
113
Category
Article
ISSN
0960-0760

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The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repeat codifies for a polyglycine tract, and affects th