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The genetic variant A of human alpha 1-acid glycoproteln limits the blood to brain transfer of drugs It binds — Pharmacological consequences

✍ Scribed by P. Jolliet; M.F. Boukef; J.C. Duche; N. Simon; J.P. Tillement


Book ID
118600907
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
179 KB
Volume
8
Category
Article
ISSN
0924-977X

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A novel probe was developed to measure drug association with the F1\*S variant of the human serum protein alpha 1-acid glycoprotein (AGP). The molecule 2hydroxy-3,5-diiodo-N-[2(diethylamino)ethyl]benzamide (DEDIC) binds to AGP, quenching its native ¯uorescence. This quenching was ®tted to a two-site