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The genetic and molecular basis of muscular dystrophy: roles of cell–matrix linkage in the pathogenesis

✍ Scribed by Motoi Kanagawa; Tatsushi Toda


Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
267 KB
Volume
51
Category
Article
ISSN
1435-232X

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As the molecular basis of Duchenne Muscular Dystrophy (DMD) was being discovered, increasing focus was placed on the mechanisms of progressive failure of myoregeneration. In this study, we propose a pathogenesis model for DMD, where an autocrine growth factor release of TGF-␤1-from necrotic myofiber