The generation of antibody diversity, a new look
β Scribed by Steiner, Lisa
- Book ID
- 123239515
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 367 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0968-0004
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the for
Most rabbit B lymphocytes use the same V H gene in V(D)J gene rearrangements and undergo somatic diversification by gene conversion and hypermutation. Recent experiments have shown that V(D)J genes in essentially all rabbit B cells diversify shortly after birth and that this diversification occurs i