𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The generation of antibody diversity, a new look

✍ Scribed by Steiner, Lisa


Book ID
123239515
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
367 KB
Volume
2
Category
Article
ISSN
0968-0004

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In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the for

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Most rabbit B lymphocytes use the same V H gene in V(D)J gene rearrangements and undergo somatic diversification by gene conversion and hypermutation. Recent experiments have shown that V(D)J genes in essentially all rabbit B cells diversify shortly after birth and that this diversification occurs i