𝔖 Bobbio Scriptorium
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Somatic generation of antibody diversity

✍ Scribed by Tonegawa, Susumu


Book ID
109730547
Publisher
Nature Publishing Group
Year
1983
Tongue
English
Weight
847 KB
Volume
302
Category
Article
ISSN
0028-0836

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πŸ“œ SIMILAR VOLUMES


Somatic generation of antibody diversity
✍ Tonegawa, Susumu πŸ“‚ Article πŸ“… 1983 πŸ› Nature Publishing Group 🌐 English βš– 847 KB

In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the for

Generating antibody diversity
✍ Sinclair, Meeghan πŸ“‚ Article πŸ“… 2000 πŸ› Nature Publishing Group 🌐 English βš– 155 KB
Generation of antibody diversity in rabb
✍ Katherine L Knight; Candace R Winstead πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 438 KB

Most rabbit B lymphocytes use the same V H gene in V(D)J gene rearrangements and undergo somatic diversification by gene conversion and hypermutation. Recent experiments have shown that V(D)J genes in essentially all rabbit B cells diversify shortly after birth and that this diversification occurs i