Generating antibody diversity
โ Scribed by Sinclair, Meeghan
- Book ID
- 109828724
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 155 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1087-0156
- DOI
- 10.1038/78394
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the for
Most rabbit B lymphocytes use the same V H gene in V(D)J gene rearrangements and undergo somatic diversification by gene conversion and hypermutation. Recent experiments have shown that V(D)J genes in essentially all rabbit B cells diversify shortly after birth and that this diversification occurs i