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The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

โœ Scribed by Ganesh, Lakshmanan; Burstein, Ezra; Guha-Niyogi, Anuradha; Louder, Mark K.; Mascola, John R.; Klomp, Leo W. J.; Wijmenga, Cisca; Duckett, Colin S.; Nabel, Gary J.


Book ID
109892554
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
388 KB
Volume
426
Category
Article
ISSN
0028-0836

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HIV-1 infection decreases the number of CD4(+) T-cells, and apoptosis has been suggested among the mechanisms. Proteins of the Shc family are involved in a complex network of signal transduction, differentiation, and apoptotic response to stress in many different cell types. Out of three homologous