✦ LIBER ✦

The gene coding for the α-chain of human propionyl-CoA carboxylase maps to chromosome band 13q32

✍ Scribed by I. Kennerknecht; T. Suormala; G. Barbi; E. R. Baumgartner

Publisher: Springer
Year: 1990
Tongue: English
Weight: 211 KB
Volume: 86
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00197713

No coin nor oath required. For personal study only.

✦ Synopsis

The human gene encoding the a-polypeptide of propionyl-CoA carboxylase (PCC) has hitherto been localized to the distal half of the long arm of chromosome 13, segment 13q22~q34. We studied the enzyme activities of mitochondrial carboxylases in cell cultures obtained from patients with different deletions of chromosome 13. By setting the PCC activity in normal diploid cell cultures (control group) at 100%, cell cultures with trisomy 13 showed 150% activity. In contrast, one of four patients with partial monosomy 13 had an enzyme activity of only 50%. Thus, by comparative deletion mapping, combined with studies of the gene-dosage effect, we have been able to assign the PCCA gene locus to chromosome band 13q32.

📜 SIMILAR VOLUMES

Mapping of the human VLA-α4 gene to chro

Mapping of the human VLA-α4 gene to chromosome 2q31-q32

✍ Elena Fernández-Ruiz; Fernando Pardo-Manuel de Villena; Miguel Angel Rubio; Ange 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 415 KB

The gene coding for the p68 calcium-bind

The gene coding for the p68 calcium-binding protein is localised to bands q32–q34 of human chromosome 5, and to mouse chromosome 11

✍ Adelina A. Davies; Stephen E. Moss; Mark R. Crompton; Tania A. Jones; Nigel K. S 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 707 KB

The gene coding for the α1 subunit of th

The gene coding for the α1 subunit of the skeletal dihydropyridine receptor (Cchl1a3=mdg) maps to mouse Chromosome 1 and human 1q32

✍ Béatrice Drouet; Luis Garcia; Dominique Simon-Chazottes; Marie Geneviève Mattei; 📂 Article 📅 1993 🏛 Springer-Verlag 🌐 English ⚖ 806 KB

Assignment of the gene coding for human

Assignment of the gene coding for human cytochromecoxidase subunit VIb to chromosome 19, band q13.1, by fluorescence in situ hybridisation

✍ Jan-Willem Taanman; Anneke Y. Veen; Cobi Schrage; Hans Vries; Charles H. C. M. B 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 762 KB

A cloned, 40 kb, genomic DNA fragment, containing the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking sequences, was used as a probe to localize the subunit VIb gene on human metaphase chromosomes. The probe was labelled with Bio-11-dUTP and detected by fluorescence

Assignment of the gene coding for human

Assignment of the gene coding for human FcRII (CD32) to bands g23g24 on chromosome 1

✍ Luke Sammartino; Lorna M. Webber; P. Mark Hogarth; Ian F. C. McKenzie; O. Margar 📂 Article 📅 1988 🏛 Springer-Verlag 🌐 English ⚖ 107 KB

Characterization of a complex chromosoma

Characterization of a complex chromosomal rearrangement maps the locus for In vitro complementation of xeroderma pigmentosum group D to human chromosome band 19q 13

✍ Wendy L. Flejter; Lisa D. McDaniel; Minoo Askari; Errol C. Friedberg; Dr. Roger 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 785 KB

## Abstract Microcell‐mediated chromosome transfer (MMCT) is a powerful genetic technique that permits the transfer of a single chromosome from one mammalian cell to another. The utility of MMCT for gene mapping strategies is critically dependent on the careful characterization of the chromosomes b