The GAP chemistry for chiral N-phosphonyl imine-based Strecker reaction
โ Scribed by Kaur, Parminder; Wever, Walter; Pindi, Suresh; Milles, Raizada; Gu, Peng; Shi, Min; Li, Guigen
- Book ID
- 120661790
- Publisher
- Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 175 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1463-9262
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๐ SIMILAR VOLUMES
Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C 2 -symmetric chiral auxiliary tolerates oxidation, is not sensi
Chiral N-phosphonyl imines attached by 1-naphthyl group were found to react with lithium malonate enolates smoothly to give chiral b-aminomalonates. Good yields and excellent diastereoselectivity were achieved for sixteen examples. The chiral auxiliary can be readily removed by treating with trifluo