Chiral N-Phosphonyl Imine Chemistry: Asymmetric Aza-Henry Reaction
โ Scribed by Adiseshu Kattuboina; Parminder Kaur; Teng Ai; Guigen Li
- Book ID
- 111368522
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 215 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1747-0277
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C 2 -symmetric chiral auxiliary tolerates oxidation, is not sensi
Chiral N-phosphonyl imines attached by 1-naphthyl group were found to react with lithium malonate enolates smoothly to give chiral b-aminomalonates. Good yields and excellent diastereoselectivity were achieved for sixteen examples. The chiral auxiliary can be readily removed by treating with trifluo