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The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition

โœ Scribed by Jason P. Covy; Benoit I. Giasson


Book ID
111184145
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
496 KB
Volume
115
Category
Article
ISSN
0022-3042

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## Abstract Multiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the __LRRK2__ gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in โˆผ1% of sporad