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The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion

✍ Scribed by Dietrich Keppler; Inka Leier; Gabriele Jedlitschky; Rosmarie Mayer; Markus Büchler


Book ID
116087220
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
828 KB
Volume
36
Category
Article
ISSN
0065-2571

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Treatment of hepatocellular carcinoma (HCC) by chemotherapy is often impeded by the intrinsic multidrug resistance (MDR) of this frequent primary cancer of the liver. The MDR phenotype can be caused by ATP-dependent export of chemotherapeutic drugs across the plasma membrane being mediated by transp