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The Frequency of the Methylenetetrahydrofolate Reductase–Gene Mutation Varies with Age in the Normal Population

✍ Scribed by Sachio Matsushita; Taro Muramatsu; Hiroyuki Arai; Toshifumi Matsui; Susumu Higuchi


Book ID
117852233
Publisher
American Society of Human Genetics
Year
1997
Tongue
English
Weight
53 KB
Volume
61
Category
Article
ISSN
0002-9297

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## Communicated by Mark Paalman Severe deficiency of methylenetetrahydrofolate reductase (MTHFR) is the most common inborn error of folate metabolism. Patients are characterized by severe hyperhomocysteinemia, homocystinuria and a variety of neurological and vascular problems. Eighteen rare mutatio