The fragile site (16) (q22)
✍ Scribed by M. Schmid; W. Feichtinger; A. Jeßberger; J. Köhler; R. Lange
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 806 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
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The rare autosomal fragile site, fra (16) (q22), is the most common of all rare autosomal fragile sites and has a heterozygote frequency of about 5%. Evidence for it was found following the segregation expected from a simple codominant trait with complete penetrance; this is in contrast to a variety
Inducibility or enhancement of fragility at 16q22 by alpha-interferon has been found in a Danish laboratory and in our laboratory. Several other studies were not able to confirm these findings. We present the results of a large study on peripheral blood lymphocytes of 15 selected controls and 146 se